The key difference between clone by clone sequencing and shotgun sequencing lies in their method of conduct. Clone by clone sequencing method involves mapping of chromosomes and cloning prior to sequencing while clone by shotgun sequencing omits both chromosome mapping and cloning steps during the sequencing.
Clone by clone sequencing and clone by shotgun sequencing are two methods of modern-day genome sequencing. Clone by clone sequencing is a more reliable method of sequencing. However, the method of clone by shotgun sequencing is faster and cheaper. The article focuses on the subtle difference between clone by clone sequencing and shotgun sequencing.
